PD 166285 dihydrochloride | Tocris Bioscience 3785 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 166285 dihydrochloride

catalog :

3785

quantity :

1 mg (also 10 mg)

price :

118 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Gaffr M, Martoriati A, Belhachemi N, Chambon J, Houliston E, Jessus C, et al. A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes. Development. 2011;138:3735-44 pubmed publisher

product information

brand :

Tocris

master code :

3785

SKU :

3785/1

product name :

PD 166285 dihydrochloride

description :

Potent Src inhibitor; also inhibits FGFR1, PDGFR and Wee1

target :

Src Family Kinase Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

99%

observed molecular weight :

585.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor (PDGFR ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.

catalog number base :

3785

product keywords :

Src FGFR PDGFRbeta PDGFRb PDGFR PDGFR Wee1 inhibitors inhibits Pfizer RTKs receptor tyrosine kinases fibroblast platelet growth factors PD166285 Src Kinases FGFR PDGFR Checkpoint Control Kinases 3785,

extended description :

Potent Src inhibitor; also inhibits FGFR1, PDGFR and Wee1

chemical name text :

6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride

formula :

C 26 H 27 Cl 2 N 5 O 2 .2HCl

formula text :

C26H27Cl2N5O2.2HCl

cas num :

212391-63-4

2020 USD :

114

2021 USD :

118 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage