PD 166285 dihydrochloride | Tocris Bioscience 3785/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 166285 dihydrochloride

catalog :

3785/1

quantity :

1 mg (also 10 mg)

price :

133 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Yin H, Zhang T, Wang H, Hu X, Hou X, Fang X, et al. Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice. Front Cell Dev Biol. 2021;9:687522 pubmed publisher
Pareja F, Brandes A, Basili T, Selenica P, Geyer F, Fan D, et al. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. Nat Commun. 2018;9:3533 pubmed publisher
Gaffr M, Martoriati A, Belhachemi N, Chambon J, Houliston E, Jessus C, et al. A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes. Development. 2011;138:3735-44 pubmed publisher

image

image 1 :

Cat.No. 3785 - PD 166285 dihydrochloride C26H27Cl2N5O2.2HCl CAS No. 212391-63-4

product information

brand :

Tocris

catalog number base :

3785

SKU :

3785/1

product name :

PD 166285 dihydrochloride

units size :

1 mg (also 10 mg)

description :

Potent Src inhibitor; also inhibits FGFR1, PDGFR and Wee1

target :

Src Family Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

585.35

url print :

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details of functionality :

PD 166285 dihydrochloride is a potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor (PDGFR ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.

top caption :

Potent Src inhibitor; also inhibits FGFR1, PDGFR and Wee1

extended description :

Potent Src inhibitor; also inhibits FGFR1, PDGFR and Wee1

chemical name text :

6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride

formula :

C26H27Cl2N5O2.2HCl

formula text :

C26H27Cl2N5O2.2HCl

cas num :

212391-63-4

USD :

133 USD

product details :

Potent Src inhibitor; also inhibits FGFR1, PDGFR and Wee1

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage