Sunitinib malate | Tocris Bioscience 3768 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sunitinib malate

catalog :

3768

quantity :

10 mg (also 50 mg)

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Mathew L, Huangyang P, Mucaj V, Lee S, Skuli N, Eisinger Mathason T, et al. Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Sci Signal. 2015;8:ra42 pubmed publisher
Goel S, Chen F, Hong H, Valdovinos H, Hernandez R, Shi S, et al. VEGFâ‚â‚‚â‚-conjugated mesoporous silica nanoparticle: a tumor targeted drug delivery system. ACS Appl Mater Interfaces. 2014;6:21677-85 pubmed publisher
Procaccia V, Nakayama H, Shimizu A, Klagsbrun M. Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochem Biophys Res Commun. 2014;448:134-8 pubmed publisher
Gaji R, Checkley L, Reese M, Ferdig M, Arrizabalaga G. Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother. 2014;58:2598-607 pubmed publisher

product information

brand :

Tocris

master code :

3768

SKU :

3768/10

product name :

Sunitinib malate

description :

Potent VEGFR, PDGFR and KIT inhibitor

target :

VEGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

532.56

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, ATP-competitive VEGFR, PDGFR and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.

catalog number base :

3768

product keywords :

Potent VEGFR PDGRb PDGFRbeta PDGFRβ FGFR inhibitors inhibits Vascular Endothelial Growth Factor Receptors KDR Flt Flk Kit Receptor Tyrosine Kinases RTKs Fibroblast platelet derived CD117 SU11248 Pfizer SU 11248 VEGFR PDGFR Other RTKs 3768, VEGFR, VEGF R

extended description :

Potent VEGFR, PDGFR and KIT inhibitor

chemical name text :

N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt

formula :

C 22 H 27 FN 4 O 2 .C 4 H 6 O 5

formula text :

C22H27FN4O2.C4H6O5

cas num :

341031-54-7

2020 USD :

228

2021 USD :

238 USD

alt names :

SU 11248

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage