Sunitinib malate | Tocris Bioscience 3768/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sunitinib malate

catalog :

3768/10

quantity :

10 mg (also 50 mg)

price :

305 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Mathew L, Huangyang P, Mucaj V, Lee S, Skuli N, Eisinger Mathason T, et al. Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Sci Signal. 2015;8:ra42 pubmed publisher
Goel S, Chen F, Hong H, Valdovinos H, Hernandez R, Shi S, et al. VEGFâ‚â‚‚â‚-conjugated mesoporous silica nanoparticle: a tumor targeted drug delivery system. ACS Appl Mater Interfaces. 2014;6:21677-85 pubmed publisher
Procaccia V, Nakayama H, Shimizu A, Klagsbrun M. Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochem Biophys Res Commun. 2014;448:134-8 pubmed publisher
Gaji R, Checkley L, Reese M, Ferdig M, Arrizabalaga G. Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother. 2014;58:2598-607 pubmed publisher

image

image 1 :

Cat.No. 3768 - Sunitinib malate C22H27FN4O2.C4H6O5 CAS No. 341031-54-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3768

SKU :

3768/10

product name :

Sunitinib malate

description :

Potent VEGFR, PDGFR and KIT inhibitor

target :

VEGF Receptor Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

532.56

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sunitinib malate is a potent, ATP-competitive VEGFR, PDGFR and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.

product keywords :

Potent VEGFR PDGRb PDGFRbeta PDGFRβ FGFR inhibitors inhibits Vascular Endothelial Growth Factor Receptors KDR Flt Flk Kit Receptor Tyrosine Kinases RTKs Fibroblast platelet derived CD117 SU11248 Pfizer SU 11248 VEGFR PDGFR Other RTKs 3768, VEGFR, VEGF R

extended description :

Potent VEGFR, PDGFR and KIT inhibitor

chemical name text :

N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt

formula :

C22H27FN4O2.C4H6O5

formula text :

C22H27FN4O2.C4H6O5

cas num :

341031-54-7

USD :

296

USD 2025 :

305 USD

product details :

Potent VEGFR, PDGFR and KIT inhibitor

alt names :

SU 11248

more info or order :

Tocris Bioscience product webpage