product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Dofetilide
catalog :
3757/5
quantity :
5 mg (also 25 mg)
price :
128 USD
more info or order :
citations: 6
Reference
McKeithan W, Feyen D, Bruyneel A, Okolotowicz K, Ryan D, Sampson K, et al. Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity. Cell Stem Cell. 2020;27:813-821.e6 pubmed publisher
Carstensen H, Hesselkilde E, Haugaard M, Flethøj M, Carlson J, Pehrson S, et al. Effects of dofetilide and ranolazine on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation. J Cardiovasc Electrophysiol. 2019;30:596-606 pubmed publisher
McKeithan W, Savchenko A, YU M, Cerignoli F, Bruyneel A, Price J, et al. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766 pubmed publisher
Carstensen H, Kjær L, Haugaard M, Flethøj M, Hesselkilde E, Kanters J, et al. Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. J Cardiovasc Pharmacol. 2018;71:26-35 pubmed publisher
Paul J, Hua S, Ilicic M, Tolosa J, Butler T, Robertson S, et al. Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor. Am J Obstet Gynecol. 2017;216:283.e1-283.e14 pubmed publisher
Bhave G, Chauder B, Liu W, Dawson E, Kadakia R, Nguyen T, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011;79:42-50 pubmed publisher
image
image 1 :
Tocris Bioscience 3757/5 image 1
Cat.No. 3757 - Dofetilide C19H27N3O5S2 CAS No. 115256-11-6
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3757
SKU :
3757/5
product name :
Dofetilide
description :
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
target :
Voltage-gated Potassium Channel Blockers
unit size :
5 mg (also 25 mg)
category :
Small Molecules
purity :
99%
storage :
Store at RT
observed molecular weight :
441.56
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Dofetilide is a selective potassium channel blocker. Blocks KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Displays class III antiarrhythmic properties.
product keywords :
UK68798 hERG K+ potassium channels blockers inhibits IKR delayed rectifier currents Kv voltage-gated voltage-dependent Human Ether-A-Go-Go Gene Pfizer KV11.1 Tikosyn UK 68798 Voltage-Gated Potassium Channels 3757,
extended description :
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
chemical name text :
1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
formula :
C19H27N3O5S2
formula text :
C19H27N3O5S2
cas num :
115256-11-6
USD :
122
USD 2025 :
128 USD
product details :
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
alt names :
Tikosyn,UK 68798
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK