Maraviroc | Tocris Bioscience 3756 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Maraviroc

catalog :

3756

quantity :

10 mg (also 50 mg)

price :

261 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Hundeyin M, Kurz E, Mishra A, Rossi J, Liudahl S, Leis K, et al. Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming. Cancer Discov. 2019;9:1288-1305 pubmed publisher
Kuratli J, Pesch T, Marti H, Leonard C, Blenn C, Torgerson P, et al. Water Filtered Infrared A and Visible Light (wIRA/VIS) Irradiation Reduces Chlamydia trachomatis Infectivity Independent of Targeted Cytokine Inhibition. Front Microbiol. 2018;9:2757 pubmed publisher
Kim B, Abdelfattah A, Vasan R, Fuchs B, Choi M. Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis. Sci Rep. 2018;8:7499 pubmed publisher
Lin S, Sun L, Lyu X, Ai X, Du D, Su N, et al. Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop. Oncotarget. 2017;8:110426-110443 pubmed publisher
Piotrowska A, Kwiatkowski K, Rojewska E, Makuch W, Mika J. Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - Evidence from in vivo and in vitro studies. Neuropharmacology. 2016;108:207-19 pubmed publisher
Marciniak E, Faivre E, Dutar P, Alves Pires C, Demeyer D, Caillierez R, et al. The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory. Sci Rep. 2015;5:15862 pubmed publisher
Lourenço S, Teixeira V, Kalber T, José R, Floto R, Janes S. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol. 2015;194:3463-74 pubmed publisher

product information

brand :

Tocris

master code :

3756

SKU :

3756/10

product name :

Maraviroc

description :

Selective CCR5 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

513.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC50 = 6.4 nM), inhibiting HIV-1 entry. Exhibits antinociceptive effects in a rat model of neuropathic pain. Also inhibits CCL3 (MIP-1 ) binding to CCR5. Orally bioavailable.

catalog number base :

3756

product keywords :

UK-427857 HIV-1 gp120 CCR5 chemokine receptors ligands selective antagonists HIV Rantes UK-427857 Chemokine CC Receptors HIV 3756,

extended description :

Selective CCR5 antagonist

chemical name text :

4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl- 5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide

formula :

C 29 H 41 F 2 N 5 O

formula text :

C29H41F2N5O

cas num :

376348-65-1

2020 USD :

255

2021 USD :

261 USD

alt names :

UK-427857

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage