Varenicline tartrate | Tocris Bioscience 3754/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Varenicline tartrate

catalog :

3754/10

quantity :

10 mg (also 50 mg)

price :

284 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Magnus C, Lee P, Bonaventura J, Zemla R, Gomez J, Ramirez M, et al. Ultrapotent chemogenetics for research and potential clinical applications. Science. 2019;364: pubmed publisher
Durham E, Howie R, Warren G, LaRue A, Cray J. Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells. Sci Rep. 2019;9:3805 pubmed publisher
Kutlu M, Tumolo J, Cann C, Gould T. Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice. Psychopharmacology (Berl). 2018;235:1211-1219 pubmed publisher
Lacroix F, Pettorelli A, Maddux J, Heidari Jam A, Chaudhri N. Varenicline Reduces Context-Induced Relapse to Alcohol-Seeking through Actions in the Nucleus Accumbens. Neuropsychopharmacology. 2017;42:1037-1048 pubmed publisher
Price K, Lillestol R, Ulens C, Lummis S. Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP. ACS Chem Neurosci. 2015;6:1151-7 pubmed publisher
Cippitelli A, Wu J, Gaiolini K, Mercatelli D, Schoch J, Gorman M, et al. AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology. Br J Pharmacol. 2015;172:1834-45 pubmed publisher
Kuryatov A, Mukherjee J, Lindstrom J. Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional ?7 AChRs. PLoS ONE. 2013;8:e62246 pubmed publisher

product information

brand :

Tocris

master code :

3754

SKU :

3754/10

rank :

0.061

product name :

Varenicline tartrate

description :

Selective 4 2 nAChR partial agonist; orally active

target :

Nicotinic (a4b2) Receptor Agonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Varenicline tartrate is an orally active, subtype-selective partial agonist at 4 2 nicotinic receptors (Ki values are 0.06, 240, 322 and 3540 nM for 4 2, 3 4, 7, 1 receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo . Also potently activates PSAM4-5-HT3 and PSAM4-GlyR chimeric ion channels (EC50 values are 4 and 1.6 nM, respectively)

extended description :

Selective 4 2 nAChR partial agonist; orally active

chemical name text :

7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate

formula :

C 13 H 13 N 3 .C 4 H 6 O 6

formula text :

C13H13N3.C4H6O6

cas num :

375815-87-5

USD :

284 USD

product details :

Selective 4 2 nAChR partial agonist; orally active

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage