Pyr3 | Tocris Bioscience 3751/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pyr3

catalog :

3751/10

quantity :

10 mg (also 50 mg)

price :

240 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Bartman C, Schiliro M, Helan M, Prakash Y, Linden D, PABELICK C. Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle. FASEB J. 2020;34:12991-13004 pubmed publisher
Szteyn K, Gomez R, Berg K, Jeske N. Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. ASN Neuro. 2015;7: pubmed publisher
Zhou H, Lin Z, Voges K, Ju C, Gao Z, Bosman L, et al. Cerebellar modules operate at different frequencies. elife. 2014;3:e02536 pubmed publisher
Senadheera S, Bertrand P, Grayson T, Leader L, Tare M, Murphy T, et al. Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. Am J Physiol Regul Integr Comp Physiol. 2013;305:R917-26 pubmed publisher
Lee C, Machold R, Witkovsky P, Rice M. TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons. J Neurosci. 2013;33:1157-68 pubmed publisher

image

image 1 :

Cat.No. 3751 - Pyr3 C16H11Cl3F3N3O3 CAS No. 1160514-60-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3751

SKU :

3751/10

product name :

Pyr3

description :

Selective TRPC3 inhibitor

target :

TRPC Channel Blockers

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

456.63

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 M) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.

product keywords :

canonical transient receptor potential TRPC3 channels inhibitors inhibits TRPC 3751,

extended description :

Selective TRPC3 inhibitor

chemical name text :

1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

formula :

C16H11Cl3F3N3O3

formula text :

C16H11Cl3F3N3O3

cas num :

1160514-60-2

USD :

237

USD 2025 :

240 USD

product details :

Selective TRPC3 inhibitor

more info or order :

Tocris Bioscience product webpage