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company name :
Tocris Bioscience
product type :
chemical
product name :
XAV 939
catalog :
3748/10
quantity :
10 mg (also 50 mg)
price :
214 USD
more info or order :
citations: 41
Reference
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Okamoto K, Ohishi T, Kuroiwa M, Iemura S, Natsume T, Seimiya H. MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs. Oncotarget. 2018;9:35844-35855 pubmed publisher
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Sousa E, Stuart H, Bates L, Ghorbani M, Nichols J, Dietmann S, et al. Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males. Cell Stem Cell. 2018;22:919-928.e6 pubmed publisher
Whitehead M, McGonigal R, Willison H, Barnett S. Heparanase attenuates axon degeneration following sciatic nerve transection. Sci Rep. 2018;8:5219 pubmed publisher
Tong K, Pellon Cardenas O, Sirihorachai V, Warder B, Kothari O, Perekatt A, et al. Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer. Cell Rep. 2017;21:3833-3845 pubmed publisher
Alsanie W, Niclis J, Hunt C, De Luzy I, Penna V, Bye C, et al. Specification of murine ground state pluripotent stem cells to regional neuronal populations. Sci Rep. 2017;7:16001 pubmed publisher
Major T, Powers A, Tabar V. Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2017;39:1H.10.1-1H.10.23 pubmed publisher
Koopmans T, Eilers R, Menzen M, Halayko A, Gosens R. ?-Catenin Directs Nuclear Factor-?B p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle. Front Immunol. 2017;8:1086 pubmed publisher
Young F, Keruzore M, Nan X, Gennet N, Bellefroid E, Li M. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. Proc Natl Acad Sci U S A. 2017;114:E5599-E5607 pubmed publisher
Dierickx P, Vermunt M, Muraro M, Creyghton M, Doevendans P, van Oudenaarden A, et al. Circadian networks in human embryonic stem cell-derived cardiomyocytes. EMBO Rep. 2017;18:1199-1212 pubmed publisher
Al Dhfyan A, Alhoshani A, Korashy H. Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation. Mol Cancer. 2017;16:14 pubmed publisher
Palpant N, Pabon L, Friedman C, Roberts M, Hadland B, Zaunbrecher R, et al. Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells. Nat Protoc. 2017;12:15-31 pubmed publisher
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product information
brand :
Tocris
master code :
3748
SKU :
3748/10
rank :
0.061
product name :
XAV 939
description :
Potent tankyrase inhibitor
target :
Tankyrase Inhibitors
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of -catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the -catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols. . XAV 939 synthesized to cGMP guidelines also available. . For more information about how XAV 939 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs
extended description :
Potent tankyrase inhibitor
chemical name text :
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
formula :
C 14 H 11 F 3 N 2 OS
formula text :
C14H11F3N2OS
cas num :
284028-89-3
USD :
214 USD
product details :
Potent tankyrase inhibitor
alt names :
XAV939 Wnt Signaling Inhibitor
storage :
Store the unopened product at room temperature. Do not use past expiration date.
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK