RN 1734 | Tocris Bioscience 3746/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RN 1734

catalog :

3746/5

quantity :

5 mg (also 25 mg)

price :

105 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Samuel R, Majd H, Richter M, Ghazizadeh Z, Zekavat S, Navickas A, et al. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell. 2020;27:876-889.e12 pubmed publisher
Hochstetler A, Smith H, Preston D, Reed M, Territo P, Shim J, et al. TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus. JCI Insight. 2020;5: pubmed publisher
Swain S, Romac J, Shahid R, Pandol S, Liedtke W, Vigna S, et al. TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. J Clin Invest. 2020;130:2527-2541 pubmed publisher
Mihara H, Uchida K, Koizumi S, Moriyama Y. Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium. PLoS ONE. 2018;13:e0206276 pubmed publisher
Mundt N, Spehr M, Lishko P. TRPV4 is the temperature-sensitive ion channel of human sperm. elife. 2018;7: pubmed publisher
Tchieu J, Zimmer B, Fattahi F, Amin S, Zeltner N, Chen S, et al. A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages. Cell Stem Cell. 2017;21:399-410.e7 pubmed publisher
Mueller Tribbensee S, Karna M, Khalil M, Neurath M, Reeh P, Engel M. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS ONE. 2015;10:e0128242 pubmed publisher
Feetham C, Nunn N, Barrett Jolley R. The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734. Front Pharmacol. 2015;6:83 pubmed publisher
Vizin R, Scarpellini C, Ishikawa D, Correa G, de Souza C, Gargaglioni L, et al. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. Acta Physiol (Oxf). 2015;214:275-89 pubmed publisher
Charrua A, Cruz C, Jansen D, Rozenberg B, Heesakkers J, Cruz F. Co-administration of transient receptor potential vanilloid 4 (TRPV4) and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis. BJU Int. 2015;115:452-60 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Butenko O, Dzamba D, Benesova J, Honsa P, Benfenati V, Rusnakova V, et al. The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. PLoS ONE. 2012;7:e39959 pubmed publisher
Shahidullah M, Mandal A, Delamere N. TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. Am J Physiol Cell Physiol. 2012;302:C1751-61 pubmed publisher
Albert E, Bec J, Desmadryl G, Chekroud K, Travo C, Gaboyard S, et al. TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. J Neurophysiol. 2012;107:3227-34 pubmed publisher
Wei X, Edelmayer R, Yan J, Dussor G. Activation of TRPV4 on dural afferents produces headache-related behavior in a preclinical rat model. Cephalalgia. 2011;31:1595-600 pubmed publisher

image

image 1 :

Cat.No. 3746 - RN 1734 C14H22Cl2N2O2S CAS No. 946387-07-1

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3746

SKU :

3746/5

product name :

RN 1734

description :

Selective TRPV4 antagonist

target :

TRPV Antagonists

unit size :

5 mg (also 25 mg)

category :

Small Molecules

storage :

Store at +4°C

observed molecular weight :

353.31

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RN 1734 is a selective TRPV4 antagonist (IC50 values are 2.3, 3.2 and 5.9 M for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, 30, 30 and 100 M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

product keywords :

RN1734 selective TRPV4 antagonists transient receptors potential channels vanilloid TRPV 3746,

extended description :

Selective TRPV4 antagonist

chemical name text :

2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

formula :

C14H22Cl2N2O2S

formula text :

C14H22Cl2N2O2S

cas num :

946387-07-1

USD :

103

USD 2025 :

105 USD

product details :

Selective TRPV4 antagonist

more info or order :

Tocris Bioscience product webpage