RN 1747 | Tocris Bioscience 3745/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RN 1747

catalog :

3745/10

quantity :

10 mg (also 50 mg)

price :

188 USD

citations: 4

Reference
Shamsaldeen Y, Lione L, Benham C. Dysregulation of TRPV4, eNOS and caveolin-1 contribute to endothelial dysfunction in the streptozotocin rat model of diabetes. Eur J Pharmacol. 2020;888:173441 pubmed publisher
Shi H, Liu C, Ding L, Zheng Y, Fei X, Lu L, et al. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol. 2015;21:4852-63 pubmed publisher
Vizin R, Scarpellini C, Ishikawa D, Correa G, de Souza C, Gargaglioni L, et al. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. Acta Physiol (Oxf). 2015;214:275-89 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3745

SKU :

3745/10

product name :

RN 1747

description :

Selective TRPV4 agonist

target :

TRPV Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

395.87

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RN 1747 is a selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 M for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, 30, 30 and 100 M for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 M).

product keywords :

RN1747 selective TRPV4 agonists transient receptors potential channels vanilloid TRPV 3745,

extended description :

Selective TRPV4 agonist

chemical name text :

1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

formula :

C17H18ClN3O4S

formula text :

C17H18ClN3O4S

cas num :

1024448-59-6

USD :

186

USD 2025 :

188 USD

product details :

Selective TRPV4 agonist