RepSox | Tocris Bioscience 3742 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RepSox

catalog :

3742

quantity :

10 mg (also 50 mg)

price :

187 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher
Segal J, Kent D, Wesche D, Ng S, Serra M, Oulès B, et al. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun. 2019;10:3350 pubmed publisher
Mou H, Vinarsky V, Tata P, Brazauskas K, Choi S, Crooke A, et al. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016;19:217-231 pubmed publisher
Lichtenberger B, Mastrogiannaki M, Watt F. Epidermal Î²-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages. Nat Commun. 2016;7:10537 pubmed publisher
Zhou A, Kozhaya L, Fujii H, Unutmaz D. GARP-TGF-? complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol. 2013;190:5057-64 pubmed publisher
Li C, Wood D, Huang J, Bhatia S. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab Chip. 2013;13:1969-78 pubmed publisher

product information

brand :

Tocris

master code :

3742

SKU :

3742/10

product name :

RepSox

description :

Potent and selective inhibitor of TGF- RI

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

287.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of the TGF- type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF- type I receptor autophosphorylation and binding respectively). Selective for TGF- type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 16 M). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.

catalog number base :

3742

product keywords :

potent inhibitors inhibits TGF- RI TGF- TGF-betaRI TGFbRI TGFbR1 tgf-b1ALK5 ALK Receptors Receptor-like Kinase Serine/Threonine Kinases RSTKs Transforming Growth Factors Beta stem cells SJN2511 ALK 5 inhibitor II RepSox SJN2511 E-616452 SJN251 E-616452 SJN 2511 ALK5 Inhibitor II TGF-beta Receptors Stem Cell Reprogramming 3742,

extended description :

Potent and selective inhibitor of TGF- RI

chemical name text :

2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

formula :

C 17 H 13 N 5

formula text :

C17H13N5

cas num :

446859-33-2

2020 USD :

178

2021 USD :

187 USD

alt names :

E-616452, SJN 2511, ALK5 Inhibitor II

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage