Indibulin | Tocris Bioscience 3728/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Indibulin

catalog :

3728/10

quantity :

10 mg (also 50 mg)

price :

198 USD

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3728

SKU :

3728/10

product name :

Indibulin

description :

Microtubule destabilizer

target :

Microtubule Binding Compounds

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at -20°C

observed molecular weight :

389.83

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Indibulin is a microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 M). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285 M). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo . Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.

product keywords :

microtubule destabilizers destabilisers mitosis tubulin tau D24851 D 24851 Microtubules Mitosis 3728,

extended description :

Microtubule destabilizer

chemical name text :

2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide

formula :

C22H16ClN3O2

formula text :

C22H16ClN3O2

cas num :

204205-90-3

USD :

220

USD 2025 :

198 USD

product details :

Microtubule destabilizer

alt names :

D 24851