product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
VU 0255035
catalog :
3727
quantity :
25 mg
price :
389 USD
more info or order :
citations: 5
Reference
Zhu H, Yan H, Tang N, Li X, Pang P, Li H, et al. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017;8:1676 pubmed publisher
Martin H, Bernabeu A, Lassalle O, Bouille C, Beurrier C, Pelissier Alicot A, et al. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Front Cell Neurosci. 2015;9:457 pubmed publisher
Rachakonda V, Jadeja R, Urrunaga N, Shah N, Ahmad D, Cheng K, et al. M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice. Sci Rep. 2015;5:14110 pubmed publisher
Shin J, Adrover M, Wess J, Alvarez V. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Proc Natl Acad Sci U S A. 2015;112:8124-9 pubmed publisher
Urrunaga N, Jadeja R, Rachakonda V, Ahmad D, McLean L, Cheng K, et al. M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury. Free Radic Biol Med. 2015;78:66-81 pubmed publisher
product information
brand :
Tocris
master code :
3727
SKU :
3727/25
product name :
VU 0255035
description :
Highly selective M1 antagonist
target :
mAChR M1 Antagonists
category :
Small Molecules
unit size :
25 mg
purity :
99%
observed molecular weight :
432.52
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Highly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.
catalog number base :
3727
product keywords :
selective muscarinic receptors M1 antagonists mAChR acetylcholine ACh VU0255035 M1 Receptors 3727,
extended description :
Highly selective M1 antagonist
chemical name text :
N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
formula :
C 18 H 20 N 6 O 3 S 2
formula text :
C18H20N6O3S2
cas num :
1135243-19-4
2020 USD :
374
2021 USD :
389 USD
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK