VU 0255035 | Tocris Bioscience 3727/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0255035

catalog :

3727/5

quantity :

5 mg (also 25 mg)

price :

120 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Zhu H, Yan H, Tang N, Li X, Pang P, Li H, et al. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017;8:1676 pubmed publisher
Martin H, Bernabeu A, Lassalle O, Bouille C, Beurrier C, Pelissier Alicot A, et al. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Front Cell Neurosci. 2015;9:457 pubmed publisher
Rachakonda V, Jadeja R, Urrunaga N, Shah N, Ahmad D, Cheng K, et al. M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice. Sci Rep. 2015;5:14110 pubmed publisher
Shin J, Adrover M, Wess J, Alvarez V. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Proc Natl Acad Sci U S A. 2015;112:8124-9 pubmed publisher
Urrunaga N, Jadeja R, Rachakonda V, Ahmad D, McLean L, Cheng K, et al. M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury. Free Radic Biol Med. 2015;78:66-81 pubmed publisher

product information

brand :

Tocris

master code :

3727

SKU :

3727/5

rank :

0.0006

product name :

VU 0255035

description :

Highly selective M1 antagonist

target :

mAChR M1 Antagonists

category :

Small Molecules

sizes available :

5 mg (also 25 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VU 0255035 is a highly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.

extended description :

Highly selective M1 antagonist

chemical name text :

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide

formula :

C 18 H 20 N 6 O 3 S 2

formula text :

C18H20N6O3S2

cas num :

1135243-19-4

USD :

120 USD

product details :

Highly selective M1 antagonist

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage