GSK 429286 | Tocris Bioscience 3726 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 429286

catalog :

3726

quantity :

1 mg (also 10 mg, 50 mg)

price :

125 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Qin E, Cooper D, Abbott K, Lennon J, Nagaraja S, Mackay A, et al. Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. Cell. 2017;170:845-859.e19 pubmed publisher
Durkin C, Leite F, Cordeiro J, Handa Y, Arakawa Y, Valderrama F, et al. RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6. Dev Cell. 2017;41:315-329.e7 pubmed publisher

product information

brand :

Tocris

master code :

3726

SKU :

3726/1

product name :

GSK 429286

description :

Selective Rho-kinase (ROCK) inhibitor

target :

Rho-kinase Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg, 50 mg)

purity :

97%

observed molecular weight :

432.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.

catalog number base :

3726

product keywords :

Selective Rho-kinases ROCK inhibitors inhibits Rho-Associated Coiled-Coil Kinases p160ROCK ROK GSK429286 GlaxoSmithKline GSK GSK429286A GSK429286A Rho-kinases 3726,

extended description :

Selective Rho-kinase (ROCK) inhibitor

chemical name text :

4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

formula :

C 21 H 16 F 4 N 4 O 2

formula text :

C21H16F4N4O2

cas num :

864082-47-3

2020 USD :

120

2021 USD :

125 USD

alt names :

GSK429286A

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage