GSK 429286 | Tocris Bioscience 3726/1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 429286

catalog :

3726/1

quantity :

1 mg (also 10 mg, 50 mg)

price :

158 USD

citations: 4

Reference
Mondal T, Shivange G, Tihagam R, Lyerly E, Battista M, Talwar D, et al. Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies. EMBO Mol Med. 2021;13:e12716 pubmed publisher
Goode D, Molliver D. Phospho-substrate profiling of Epac-dependent protein kinase C activity. Mol Cell Biochem. 2019;456:167-178 pubmed publisher
Qin E, Cooper D, Abbott K, Lennon J, Nagaraja S, Mackay A, et al. Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. Cell. 2017;170:845-859.e19 pubmed publisher
Durkin C, Leite F, Cordeiro J, Handa Y, Arakawa Y, Valderrama F, et al. RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6. Dev Cell. 2017;41:315-329.e7 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3726

SKU :

3726/1

product name :

GSK 429286

description :

Selective Rho-kinase (ROCK) inhibitor

target :

Rho-kinase Inhibitors

unit size :

1 mg (also 10 mg, 50 mg)

category :

Small Molecules

purity :

97%

storage :

Store at +4°C

observed molecular weight :

432.37

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 429286 is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenaline-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.

product keywords :

Selective Rho-kinases ROCK inhibitors inhibits Rho-Associated Coiled-Coil Kinases p160ROCK ROK GSK429286 GlaxoSmithKline GSK GSK429286A GSK429286A Rho-kinases 3726,

extended description :

Selective Rho-kinase (ROCK) inhibitor

chemical name text :

4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

formula :

C21H16F4N4O2

formula text :

C21H16F4N4O2

cas num :

864082-47-3

USD :

156

USD 2025 :

158 USD

product details :

Selective Rho-kinase (ROCK) inhibitor

alt names :

GSK429286A