KU 0063794 | Tocris Bioscience 3725/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KU 0063794

catalog :

3725/10

quantity :

10 mg

price :

339 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Tooley A, Kazyken D, Bodur C, Gonzalez I, Fingar D. The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt. J Biol Chem. 2021;297:100942 pubmed publisher
Martínez Fábregas J, Wang L, Pohler E, Cozzani A, Wilmes S, Kazemian M, et al. CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci. Cell Rep. 2020;33:108545 pubmed publisher
Xing T, Hass D, Zhang S, Barnstable C. The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development. Front Cell Dev Biol. 2018;6:134 pubmed publisher
Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, et al. SYK kinase mediates brown fat differentiation and activation. Nat Commun. 2017;8:2115 pubmed publisher
Bodur C, Kazyken D, Huang K, Ekim Üstünel B, Siroky K, Tooley A, et al. The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists. EMBO J. 2018;37:19-38 pubmed publisher
Yang J, Waldron R, Su H, Moro A, Chang H, Eibl G, et al. Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2016;311:G675-G687 pubmed publisher
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed publisher
Hukelmann J, Anderson K, Sinclair L, Grzes K, Murillo A, Hawkins P, et al. The cytotoxic T cell proteome and its shaping by the kinase mTOR. Nat Immunol. 2016;17:104-12 pubmed publisher
Munson M, Allen G, Toth R, Campbell D, Lucocq J, Ganley I. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J. 2015;34:2272-90 pubmed publisher
LÃ³pez Cotarelo P, Escribano DÃaz C, GonzÃ¡lez Bethencourt I, GÃ³mez Moreira C, Deguiz M, Torres Bacete J, et al. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. J Biol Chem. 2015;290:827-40 pubmed publisher
Wang C, Held R, Hall B. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS ONE. 2013;8:e83941 pubmed publisher
Sengupta S, Lorente Rodríguez A, Earnest S, Stippec S, Guo X, Trudgian D, et al. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Proc Natl Acad Sci U S A. 2013;110:18826-31 pubmed publisher
Montané M, Menand B. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Exp Bot. 2013;64:4361-74 pubmed publisher
Fei S, Zhang X, Dong S, Cheng H, Zhang Y, Huang L, et al. Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells. PLoS ONE. 2013;8:e69104 pubmed publisher

image

image 1 :

Cat.No. 3725 - KU 0063794 C25H31N5O4 CAS No. 938440-64-3

product information

brand :

Tocris

MasterCode :

3725

SKU :

3725/10

product name :

KU 0063794

target :

mTOR Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

465.54

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

KU 0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro .

extended description :

Selective mTOR inhibitor

chemical name text :

rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

formula :

C 25 H 31 N 5 O 4

formula text :

C25H31N5O4

cas num :

938440-64-3

USD :

339 USD

product details :

Selective mTOR inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage