chemical

Reversan

3722

10 mg (also 50 mg)

227 USD

3722

3722/10

Reversan

Selective MRP1 and P-gp inhibitor

Multidrug Transporter Inhibitors

Small Molecules

10 mg (also 50 mg)

99%

441.52

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

3722

MRP1 p-glycoprotein p-gp multidrug resistance associated protein 1 transporters inhibitors inhibits selective ABCB1 Multidrug Transporters 3722,

Selective MRP1 and P-gp inhibitor

N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

C 26 H 27 N 5 O 2

C26H27N5O2

313397-13-6

222

227 USD

Store at RT