Reversan | Tocris Bioscience 3722/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Reversan

catalog :

3722/10

quantity :

10 mg (also 50 mg)

price :

282 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Low F, Shabir K, Brown J, Bill R, Rothnie A. Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines. Int J Mol Sci. 2020;21: pubmed publisher

image

image 1 :

Cat.No. 3722 - Reversan C26H27N5O2 CAS No. 313397-13-6

product information

brand :

Tocris

MasterCode :

3722

SKU :

3722/10

product name :

Reversan

target :

Multidrug Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

95%

observed molecular weight :

441.52

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

extended description :

Selective MRP1 and P-gp inhibitor

chemical name text :

N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

formula :

C 26 H 27 N 5 O 2

formula text :

C26H27N5O2

cas num :

313397-13-6

USD :

282 USD

product details :

Selective MRP1 and P-gp inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage