SR 48692 | Tocris Bioscience 3721/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SR 48692

catalog :

3721/5

quantity :

5 mg (also 25 mg)

price :

184 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle S, Morstein L, et al. Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv. 2021;7: pubmed publisher
Rouibi K, Bose P, RomprÃ© P, Warren R. Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin. Front Neurosci. 2015;9:470 pubmed publisher
Piccart E, Courtney N, Branch S, Ford C, Beckstead M. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci. 2015;35:11144-52 pubmed publisher
Bakirtzi K, West G, Fiocchi C, Law I, Iliopoulos D, Pothoulakis C. The neurotensin-HIF-1Î±-VEGFÎ± axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis. Am J Pathol. 2014;184:3405-14 pubmed publisher
Toda H, Boku S, Nakagawa S, Inoue T, Kato A, Takamura N, et al. Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat amygdala. PLoS ONE. 2014;9:e97421 pubmed publisher
Moody T, Chan D, Mantey S, Moreno P, Jensen R. SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner. Life Sci. 2014;100:25-34 pubmed publisher
Alysandratos K, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H, et al. Neurotensin and CRH interactions augment human mast cell activation. PLoS ONE. 2012;7:e48934 pubmed publisher

product information

brand :

Tocris

master code :

3721

SKU :

3721/5

rank :

0.0006

product name :

SR 48692

description :

Selective non-peptide NTS1 antagonist

target :

Neurotensin Receptor Antagonists

category :

Small Molecules

sizes available :

5 mg (also 25 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SR 48692 is a neurotensin antagonist; selective for NTS1 over NTS2 (apparent affinity, Ke, is 36 nM for NTS1). Competitively inhibits binding of [125I]-neurotensin to HT29 and N1E115 cell membranes (IC50 values are 15.3 and 20.4 nM respectively). Orally bioavailable.

extended description :

Selective non-peptide NTS1 antagonist

chemical name text :

2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid

formula :

C 32 H 31 ClN 4 O 5

formula text :

C32H31ClN4O5

cas num :

146362-70-1

USD :

184 USD

product details :

Selective non-peptide NTS1 antagonist

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage