Talabostat mesylate | Tocris Bioscience 3719/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Talabostat mesylate

catalog :

3719/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Orth He E, Huang H, Rao S, Wang Q, Chen Q, O Mara C, et al. Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Cell Rep. 2023;42:111965 pubmed publisher
Hsiao J, Neugroschl A, Chui A, Taabazuing C, Griswold A, Wang Q, et al. A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome. J Biol Chem. 2022;298:102032 pubmed publisher
Rao S, Chen Q, Wang Q, Orth He E, Saoi M, Griswold A, et al. M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome. Nat Chem Biol. 2022;18:565-574 pubmed publisher
Casazza A, Van Helleputte L, Van Renterghem B, Pokreisz P, De Geest N, De Petrini M, et al. PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index. Mol Cancer Ther. 2022;21:568-581 pubmed publisher
Al Rifai O, Julien C, LaCombe J, Faubert D, Lira Navarrete E, Narimatsu Y, et al. The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans. elife. 2020;9: pubmed publisher
Okondo M, Johnson D, Sridharan R, Go E, Chui A, Wang M, et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017;13:46-53 pubmed publisher

product information

brand :

Tocris

MasterCode :

3719

SKU :

3719/10

product name :

Talabostat mesylate

target :

Inflammasomes Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

310.18

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Talabostat mesylate is a potent DPP IV inhibitor (IC50 values are 4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.

extended description :

Potent DPP IV inhibitor; activates NLRP1b inflammasome

chemical name text :

B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate

formula :

C 9 H 19 BN 2 O 3 .CH 3 SO 3 H

formula text :

C9H19BN2O3.CH3SO3H

cas num :

150080-09-4

USD :

219 USD

product details :

Potent DPP IV inhibitor; activates NLRP1b inflammasome

alt names :

Val-boroPro, BXCL 701

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage