AS 1949490 | Tocris Bioscience 3718/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AS 1949490

catalog :

3718/5

quantity :

5 mg (also 25 mg)

price :

120 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Fernandes S, Srivastava N, Pedicone C, Sudan R, Luke E, Dungan O, et al. Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment. iScience. 2023;26:106071 pubmed publisher
Hlushchuk I, Barut J, Airavaara M, Luk K, Domanskyi A, Chmielarz P. Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons. Biomolecules. 2022;12: pubmed publisher
Feng Z, Yu C. PI(3,4)P2-mediated membrane tubulation promotes integrin trafficking and invasive cell migration. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Polianskyte Prause Z, Tolvanen T, Lindfors S, Dumont V, Van M, Wang H, et al. Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. FASEB J. 2019;33:2858-2869 pubmed publisher
Chan Wah Hak L, Khan S, Di Meglio I, Law A, Lucken Ardjomande Häsler S, Quintaneiro L, et al. FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Nat Cell Biol. 2018;20:1023-1031 pubmed publisher
Ghosh S, Scozzaro S, Ramos A, Delcambre S, Chevalier C, Krejci P, et al. Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells. J Cell Sci. 2018;131: pubmed publisher
Ghosh S, Huber C, Siour Q, Sousa S, Wright M, Cormier Daire V, et al. Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects. Hum Mutat. 2017;38:1731-1739 pubmed publisher
Zhang S, Duan L, He S, Zhuang G, Yu X. Phosphatidylinositol 3,4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation. Cell Res. 2017;27:253-273 pubmed publisher
Hughes S, Oudin M, Tadros J, Neil J, Del Rosario A, Joughin B, et al. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Mol Biol Cell. 2015;26:3867-78 pubmed publisher
Boucrot E, Ferreira A, Almeida Souza L, Debard S, Vallis Y, Howard G, et al. Endophilin marks and controls a clathrin-independent endocytic pathway. Nature. 2015;517:460-5 pubmed publisher
Chang P, Walker M, Williams R. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol Dis. 2014;62:296-306 pubmed publisher

image

image 1 :

Cat.No. 3718 - AS 1949490 C20H18ClNO2S CAS No. 1203680-76-5

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3718

SKU :

3718/5

product name :

AS 1949490

description :

SH2 domain-containing inositol 5 -phosphatase 2 (SHIP2) inhibitor

target :

Inositol Phosphatase Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

371.88

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AS 1949490 is a selective SHIP2 (SH2 domain-containing inositol 5 -phosphatase 2) inhibitor (IC50 values are 0.34 M and 0.62 M for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. Also promotes increased BDNF mRNA levels in cultured cortical neurons and has memory enhancing and antidepressant effects in vivo .

product keywords :

AS1949490 SHIP2 inhibitor inhibits SH2 domain containing inositol 5 phosphate 2 diabetes antidiabetic inhibitors Inositol Phosphatases 3718,

extended description :

SH2 domain-containing inositol 5 -phosphatase 2 (SHIP2) inhibitor

chemical name text :

3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide

formula :

C20H18ClNO2S

formula text :

C20H18ClNO2S

cas num :

1203680-76-5

USD :

118

USD 2025 :

120 USD

product details :

SH2 domain-containing inositol 5 -phosphatase 2 (SHIP2) inhibitor

more info or order :

Tocris Bioscience product webpage