Narciclasine | Tocris Bioscience 3715/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Narciclasine

catalog :

3715/1

quantity :

1 mg

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Duman J, Mulherkar S, Tu Y, Erikson K, Tzeng C, Mavratsas V, et al. The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. elife. 2019;8: pubmed publisher

product information

brand :

Tocris

master code :

3715

SKU :

3715/1

rank :

0.061

product name :

Narciclasine

description :

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

target :

Other Rho GTPase Compounds

category :

Small Molecules

sizes available :

1 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Narciclasine is an exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro . Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.

extended description :

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

chemical name text :

(2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one

formula :

C 14 H 13 NO 7

formula text :

C14H13NO7

cas num :

29477-83-6

USD :

212 USD

product details :

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage