product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
NU 7441
catalog :
3712/10
quantity :
10 mg (also 50 mg)
price :
267 USD
more info or order :
citations: 42
Reference
NGUYEN J, Haidar F, Fox A, Ray C, Mendonça D, Kim J, et al. mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer. iScience. 2019;17:190-207 pubmed publisher
Martínez Macías M, Moore D, Green R, Gómez Herreros F, Naumann M, Hermann A, et al. FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress. Life Sci Alliance. 2019;2: pubmed publisher
Balmus G, Pilger D, Coates J, Demir M, Sczaniecka Clift M, Barros A, et al. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nat Commun. 2019;10:87 pubmed publisher
Amiri Moghani A, Sharma M, Matsumoto Y. In cellulo phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK. J Radiat Res. 2018;59:700-708 pubmed publisher
Calo E, Gu B, Bowen M, Aryan F, Zalc A, Liang J, et al. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 2018;554:112-117 pubmed publisher
Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, et al. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. Nat Commun. 2018;9:335 pubmed publisher
Edwards T, Bloom D, Fisher C. The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication. J Virol. 2018;92: pubmed publisher
Hamada N. Ionizing radiation response of primary normal human lens epithelial cells. PLoS ONE. 2017;12:e0181530 pubmed publisher
Biehs R, Steinlage M, Barton O, Juhasz S, Künzel J, Spies J, et al. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol Cell. 2017;65:671-684.e5 pubmed publisher
Lamaa A, Le Bras M, Skuli N, Britton S, Frit P, Calsou P, et al. A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function. EMBO Rep. 2016;17:508-18 pubmed publisher
Deng X, Yan Z, Cheng F, Engelhardt J, Qiu J. Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways. PLoS Pathog. 2016;12:e1005399 pubmed publisher
Bunch H, Lawney B, Lin Y, Asaithamby A, Murshid A, Wang Y, et al. Transcriptional elongation requires DNA break-induced signalling. Nat Commun. 2015;6:10191 pubmed publisher
Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher
Rein K, Yanez D, Terré B, Palenzuela L, Aivio S, Wei K, et al. EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele. Nucleic Acids Res. 2015;43:7371-87 pubmed publisher
Hollingworth R, Skalka G, Stewart G, Hislop A, Blackbourn D, Grand R. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Viruses. 2015;7:2908-27 pubmed publisher
Colin D, Hain K, Allan L, Clarke P. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biol. 2015;5:140156 pubmed publisher
Yu L, Shang Z, Hsu F, Zhang Z, Tumati V, Lin Y, et al. NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor. Oncotarget. 2015;6:3848-60 pubmed
Mishra A, Brown A, Yao X, Yang S, Park S, Liu C, et al. Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. Nat Commun. 2015;6:6224 pubmed publisher
Thakran S, Zhang Q, Morales Tirado V, Steinle J. Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. Invest Ophthalmol Vis Sci. 2014;56:177-84 pubmed publisher
Henriksson S, Rassoolzadeh H, Hedström E, Coucoravas C, Julner A, Goldstein M, et al. The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev. 2014;28:2726-38 pubmed publisher
Zhou Z, Patel M, Ng N, Hsieh M, Orth A, Walker J, et al. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. BMC Cancer. 2014;14:944 pubmed publisher
Jones R, Kotsantis P, Stewart G, Groth P, Petermann E. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine. Mol Cancer Ther. 2014;13:2412-21 pubmed publisher
Soni A, Siemann M, Grabos M, Murmann T, Pantelias G, Iliakis G. Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining. Nucleic Acids Res. 2014;42:6380-92 pubmed publisher
Scanlon S, Glazer P. Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins. Mol Cancer Res. 2014;12:1016-28 pubmed publisher
Zhou Y, Paull T. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J Biol Chem. 2013;288:37112-25 pubmed publisher
Britton S, Coates J, Jackson S. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J Cell Biol. 2013;202:579-95 pubmed publisher
Song H, Hedayati M, Hobbs R, Shao C, Bruchertseifer F, Morgenstern A, et al. Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody. Mol Cancer Ther. 2013;12:2043-54 pubmed publisher
Lee B, Gapud E, Zhang S, Dorsett Y, Bredemeyer A, George R, et al. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol. 2013;33:3568-79 pubmed publisher
Sonego M, Schiappacassi M, Lovisa S, Dall Acqua A, Bagnoli M, Lovat F, et al. Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer. EMBO Mol Med. 2013;5:707-22 pubmed publisher
Zhang Q, Steinle J. DNA-PK phosphorylation of IGFBP-3 is required to prevent apoptosis in retinal endothelial cells cultured in high glucose. Invest Ophthalmol Vis Sci. 2013;54:3052-7 pubmed publisher
Edwards T, Helmus M, Koeller K, Bashkin J, Fisher C. Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways. J Virol. 2013;87:3979-89 pubmed publisher
Rass E, Chandramouly G, Zha S, Alt F, Xie A. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem. 2013;288:7086-95 pubmed publisher
Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, et al. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013;110:2234-9 pubmed publisher
Sultana R, Abdel Fatah T, Abbotts R, Hawkes C, Albarakati N, Seedhouse C, et al. Targeting XRCC1 deficiency in breast cancer for personalized therapy. Cancer Res. 2013;73:1621-34 pubmed publisher
Yüce O, West S. Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. Mol Cell Biol. 2013;33:406-17 pubmed publisher
Neumayer G, Helfricht A, Shim S, Le H, Lundin C, Belzil C, et al. Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates ?-histone 2AX (?-H2AX) levels upon ionizing radiation. J Biol Chem. 2012;287:42206-22 pubmed publisher
Yamamoto K, Wang Y, Jiang W, Liu X, Dubois R, Lin C, et al. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol. 2012;198:305-13 pubmed publisher
Sultana R, McNeill D, Abbotts R, Mohammed M, Zdzienicka M, Qutob H, et al. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors. Int J Cancer. 2012;131:2433-44 pubmed publisher
Sharma A, Bode B, Wenger R, Lehmann K, Sartori A, Moch H, et al. ?-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo. PLoS ONE. 2011;6:e28217 pubmed publisher
Luo Y, Lou S, Deng X, Liu Z, Li Y, Kleiboeker S, et al. Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol. 2011;85:8046-55 pubmed publisher
Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, et al. Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet. 2011;7:e1001381 pubmed publisher
Cataldi M, McCarty D. Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes. J Virol. 2010;84:8673-82 pubmed publisher
product information
brand :
Tocris
master code :
3712
SKU :
3712/10
rank :
0.061
product name :
NU 7441
description :
Potent and selective DNA-PK inhibitor
target :
DNA-dependent Protein Kinase Inhibitors
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NU 7441 is a potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo . Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%.
extended description :
Potent and selective DNA-PK inhibitor
chemical name text :
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
formula :
C 25 H 19 NO 3 S
formula text :
C25H19NO3S
cas num :
503468-95-9
USD :
267 USD
product details :
Potent and selective DNA-PK inhibitor
alt names :
KU 57788
storage :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK