A 740003 | Tocris Bioscience 3701 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 740003

catalog :

3701

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Bergamin L, Capece M, Salaro E, Sarti A, Falzoni S, Pereira M, et al. Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth. Oncotarget. 2019;10:4840-4856 pubmed publisher
Zumerle S, Calì B, Munari F, Angioni R, Di Virgilio F, Molon B, et al. Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis. Cell Rep. 2019;27:1-10.e4 pubmed publisher
De Marchi E, Orioli E, Pegoraro A, Sangaletti S, Portararo P, Curti A, et al. The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment. Oncogene. 2019;38:3636-3650 pubmed publisher
Gilbert S, Oliphant C, Hassan S, Peille A, Bronsert P, Falzoni S, et al. ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival. Oncogene. 2019;38:194-208 pubmed publisher
Agrawal A, Henriksen Z, Syberg S, Petersen S, Aslan D, Solgaard M, et al. P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts. Bone. 2017;95:91-101 pubmed publisher
Adamczyk M, Griffiths R, Dewitt S, Knauper V, Aeschlimann D. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. J Cell Sci. 2015;128:4615-28 pubmed publisher
Englezou P, Rothwell S, Ainscough J, Brough D, Landsiedel R, Verkhratsky A, et al. P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages. Cytokine. 2015;74:293-304 pubmed publisher
Song X, Xu X, Zhu J, Guo Z, Li J, He C, et al. Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury. Purinergic Signal. 2015;11:203-13 pubmed publisher
Ashpole N, Chawla A, Martin M, Brustovetsky T, Brustovetsky N, Hudmon A. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP. J Biol Chem. 2013;288:14599-611 pubmed publisher
Amoroso F, Falzoni S, Adinolfi E, Ferrari D, Di Virgilio F. The P2X7 receptor is a key modulator of aerobic glycolysis. Cell Death Dis. 2012;3:e370 pubmed publisher
Hazleton J, Berman J, Eugenin E. Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol. 2012;188:4488-95 pubmed publisher
Grol M, Zelner I, Dixon S. P2X?-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells. Am J Physiol Endocrinol Metab. 2012;302:E561-75 pubmed publisher

product information

brand :

Tocris

master code :

3701

SKU :

3701/10

product name :

A 740003

description :

Potent and selective P2X7 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

474.55

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 M. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.

catalog number base :

3701

product keywords :

A740003 potent selective P2X7 receptors antagonists purinergics purinoceptors P2X Receptors 3701,

extended description :

Potent and selective P2X7 antagonist

chemical name text :

N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide

formula :

C 26 H 30 N 6 O 3

formula text :

C26H30N6O3

cas num :

861393-28-4

2020 USD :

187

2021 USD :

195 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage