DL-AP5 Sodium salt | Tocris Bioscience 3693/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DL-AP5 Sodium salt

catalog :

3693/10

quantity :

10 mg (also 50 mg)

price :

97 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Pati S, Saba K, Salvi S, Tiwari P, Chaudhari P, Verma V, et al. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior. elife. 2020;9: pubmed publisher
Zhao J, Li A, Rajsombath M, Dang Y, Selkoe D, Li S. Soluble A? Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience. 2018;6:138-150 pubmed publisher
Athilingam J, Ben Shalom R, Keeshen C, Sohal V, Bender K. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. elife. 2017;6: pubmed publisher
Maschi D, Klyachko V. Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses. Neuron. 2017;94:65-73.e3 pubmed publisher
Cazares V, Njus M, Manly A, Saldate J, Subramani A, Ben Simon Y, et al. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn. J Neurosci. 2016;36:11208-11222 pubmed
Pan G, Yang J, Hu X, Li X. Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice. Sci Rep. 2016;6:28137 pubmed publisher
Thomsen E, Mich J, Yao Z, Hodge R, Doyle A, Jang S, et al. Fixed single-cell transcriptomic characterization of human radial glial diversity. Nat Methods. 2016;13:87-93 pubmed publisher
Falgairolle M, O Donovan M. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS ONE. 2015;10:e0131430 pubmed publisher

product information

brand :

Tocris

master code :

3693

SKU :

3693/10

rank :

0.061

product name :

DL-AP5 Sodium salt

description :

Potent and selective NMDA antagonist; sodium salt of DL-AP5

target :

NMDA Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons. . DL mixture, D-isomer and L-isomer also available.

extended description :

Potent and selective NMDA antagonist; sodium salt of DL-AP5

chemical name text :

DL-2-Amino-5-phosphonopentanoic acid sodium salt

formula :

C 5 H 11 NNaO 5 P

formula text :

C5H11NNaO5P

cas num :

1303993-72-7

USD :

97 USD

product details :

Potent and selective NMDA antagonist; sodium salt of DL-AP5

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage