CITCO | Tocris Bioscience 3683 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CITCO

catalog :

3683

quantity :

10 mg (also 50 mg)

price :

151 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
McMahon M, Ding S, Jimenez L, Terranova R, Gerard M, Vitobello A, et al. Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes. Mol Pharmacol. 2019;95:97-105 pubmed publisher
Cherian M, Lin W, Wu J, Chen T. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol Pharmacol. 2015;87:878-89 pubmed publisher
Yueh M, Li T, Evans R, Hammock B, Tukey R. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS ONE. 2012;7:e37705 pubmed publisher

product information

brand :

Tocris

master code :

3683

SKU :

3683/10

product name :

CITCO

description :

Selective CAR agonist

target :

VDR-like Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

436.74

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Constitutive androstane receptor (CAR) agonist (EC50 = 49 nM). Displays 100-fold selectivity over PXR receptors and no activity at LXR, ER , ER , PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro .

catalog number base :

3683

product keywords :

Selective CAR agonists Constitutive androstane VDR-like receptors Constitutive Androstane Receptor 3683,

extended description :

Selective CAR agonist

chemical name text :

6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime

formula :

C 19 H 12 Cl 3 N 3 OS

formula text :

C19H12Cl3N3OS

cas num :

338404-52-7

2020 USD :

145

2021 USD :

151 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage