CITCO | Tocris Bioscience 3683/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CITCO

catalog :

3683/10

quantity :

10 mg (also 50 mg)

price :

191 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Stefela A, Kaspar M, Drastík M, Kronenberger T, Micuda S, Dracinsky M, et al. (E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells. Front Pharmacol. 2021;12:713149 pubmed publisher
McMahon M, Ding S, Jimenez L, Terranova R, Gerard M, Vitobello A, et al. Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes. Mol Pharmacol. 2019;95:97-105 pubmed publisher
Cherian M, Lin W, Wu J, Chen T. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol Pharmacol. 2015;87:878-89 pubmed publisher
Yueh M, Li T, Evans R, Hammock B, Tukey R. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS ONE. 2012;7:e37705 pubmed publisher

image

image 1 :

Cat.No. 3683 - CITCO C19H12Cl3N3OS CAS No. 338404-52-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3683

SKU :

3683/10

product name :

CITCO

description :

Selective CAR agonist

target :

VDR-like Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at -20°C

observed molecular weight :

436.74

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CITCO is a constitutive androstane receptor (CAR) agonist (EC50 = 49 nM). Displays 100-fold selectivity over PXR receptors and no activity at LXR, ER , ER , PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro .

product keywords :

Selective CAR agonists Constitutive androstane VDR-like receptors Constitutive Androstane Receptor 3683,

extended description :

Selective CAR agonist

chemical name text :

6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime

formula :

C19H12Cl3N3OS

formula text :

C19H12Cl3N3OS

cas num :

338404-52-7

USD :

189

USD 2025 :

191 USD

product details :

Selective CAR agonist

more info or order :

Tocris Bioscience product webpage