DS2 | Tocris Bioscience 3679 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DS2

catalog :

3679

quantity :

10 mg (also 50 mg)

price :

184 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Olander E, Madjroh N, Bunch L, Söderhielm P, Jensen A. Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem Pharmacol. 2018;150:305-319 pubmed publisher
Patel B, Bright D, Mortensen M, FrÃ¸lund B, Smart T. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci. 2016;36:607-21 pubmed publisher
Tong X, Peng Z, Zhang N, Cetina Y, Huang C, Wallner M, et al. Ectopic Expression of Î±6 and Î´ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. J Neurosci. 2015;35:16142-58 pubmed publisher
Hammer H, Ebert B, Jensen H, Jensen A. Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes. PLoS ONE. 2015;10:e0120239 pubmed publisher
Kerti Szigeti K, Nusser Z, Eyre M. Synaptic GABAA receptor clustering without the Î³2 subunit. J Neurosci. 2014;34:10219-33 pubmed publisher
Mennerick S, Taylor A, Zorumski C. Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function. Psychopharmacology (Berl). 2014;231:3493-501 pubmed publisher
Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic M, et al. Unexpected Properties of ?-Containing GABAA Receptors in Response to Ligands Interacting with the ?+ ?- Site. Neurochem Res. 2014;39:1057-1067 pubmed publisher
Shu H, Bracamontes J, Taylor A, Wu K, Eaton M, Akk G, et al. Characteristics of concatemeric GABA(A) receptors containing ?4/? subunits expressed in Xenopus oocytes. Br J Pharmacol. 2012;165:2228-43 pubmed publisher

product information

brand :

Tocris

master code :

3679

SKU :

3679/10

product name :

DS2

description :

Positive allosteric modulator of GABAA receptors; displays subunit selectivity

target :

GABA-A Receptor Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

353.83

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Positive allosteric modulator of GABAA receptors. Potentiates GABA-evoked currents mediated by 4 3 receptors (EC50 = 142 nM, in vitro ). Displays complex selectivity profile, with selectivity for -containing receptors ( 4/6 x 1 x 2 4 3 GABAA receptors). Enhances tonic currents of thalamocortical neurons in wild-type mice.

catalog number base :

3679

product keywords :

Positive allosteric modulators delta GABAA receptors PAM GABAA Receptors 3679,

extended description :

Positive allosteric modulator of GABAA receptors; displays subunit selectivity

chemical name text :

4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide

formula :

C 18 H 12 ClN 3 OS

formula text :

C18H12ClN3OS

cas num :

374084-31-8

2020 USD :

176

2021 USD :

184 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage