TMCB | Tocris Bioscience 3675/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TMCB

catalog :

3675/10

quantity :

10 mg (also 50 mg)

price :

118 USD

citations: 1

Reference
Schevzov G, Kee A, Wang B, Sequeira V, Hook J, Coombes J, et al. Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Mol Biol Cell. 2015;26:2475-90 pubmed publisher

product information

brand :

Tocris

master code :

3675

SKU :

3675/10

product name :

TMCB

description :

Dual-kinase inhibitor; inhibits CK2 and ERK8

target :

Casein Kinase 2 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

534.82

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TMCB is a dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 M for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 M for CK2, PIM1, DYRK1a and HIPK2 respectively).

catalog number base :

3675

extended description :

Dual-kinase inhibitor; inhibits CK2 and ERK8

chemical name text :

2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid

formula :

C 11 H 9 Br 4 N 3 O 2

formula text :

C11H9Br4N3O2

cas num :

905105-89-7

USD 2021 :

115

USD 2022 :

118 USD

product details :

Dual-kinase inhibitor; inhibits CK2 and ERK8

storage :

Store at RT