BMS 195614 | Tocris Bioscience 3660/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS 195614

catalog :

3660/10

quantity :

10 mg (also 50 mg)

price :

308 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Metzler M, Raja S, Elliott K, Friedl R, Tran N, Brugmann S, et al. RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018;145: pubmed publisher
Flamini M, Gauna G, Sottile M, Nadin B, Sanchez A, Vargas Roig L. Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta. J Cell Mol Med. 2014;18:1113-23 pubmed publisher
Johansson H, Sanchez B, Mundt F, Forshed J, Kovács A, Panizza E, et al. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun. 2013;4:2175 pubmed publisher
Liang D, Zuo A, Shao H, Born W, O Brien R, Kaplan H, et al. Retinoic acid inhibits CD25+ dendritic cell expansion and ?? T-cell activation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2013;54:3493-503 pubmed publisher
Chen X, Dodge J, Komorowski R, Drobyski W. A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease. Blood. 2013;121:3970-80 pubmed publisher

product information

brand :

Tocris

master code :

3660

SKU :

3660/10

rank :

0.061

product name :

BMS 195614

description :

Selective RAR antagonist

target :

Retinoic Acid Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BMS 195614 is a neutral retinoic acid receptor (RAR) -selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.

extended description :

Selective RAR antagonist

chemical name text :

4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid

formula :

C 29 H 24 N 2 O 3

formula text :

C29H24N2O3

cas num :

182135-66-6

USD :

308 USD

product details :

Selective RAR antagonist

alt names :

BMS614

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage