SB 328437 | Tocris Bioscience 3650/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 328437

catalog :

3650/10

quantity :

10 mg

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Abonyo B, Alexander M, Heiman A. Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2005;289:L478-88 pubmed

product information

brand :

Tocris

master code :

3650

SKU :

3650/10

rank :

0.071

product name :

SB 328437

description :

Potent and selective CCR3 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 328437 is a potent and selective CCR3 antagonist (IC50 = 4 nM). Displays 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca2+ mobilization (IC50 values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.

extended description :

Potent and selective CCR3 antagonist

chemical name text :

N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester

formula :

C 21 H 18 N 2 O 5

formula text :

C21H18N2O5

cas num :

247580-43-4

USD :

227 USD

product details :

Potent and selective CCR3 antagonist

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage