FK 506 | Tocris Bioscience 3631/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FK 506

catalog :

3631/10

quantity :

10 mg

price :

191 USD

more info or order :

Tocris Bioscience product webpage

citations: 19

Reference
Chiu A, Wang J, Fiske M, Hubálková P, Barse L, Gray J, et al. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep. 2019;28:332-341.e5 pubmed publisher
Torres A, Arriagada V, Erices J, Toro M, Rocha J, Niechi I, et al. FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells. Int J Mol Sci. 2018;19: pubmed publisher
Neustadtl A, Winston C, Parsadanian M, Main B, Villapol S, Burns M. Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. Neuroreport. 2017;28:618-624 pubmed publisher
Henson M, Tucker C, Zhao M, Dudek S. Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning. Neurobiol Learn Mem. 2017;138:39-53 pubmed publisher
Matsa E, Burridge P, Yu K, Ahrens J, Termglinchan V, Wu H, et al. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses InÂ Vitro. Cell Stem Cell. 2016;19:311-25 pubmed publisher
Palmqvist N, Siller M, Klint C, Sjödin A. A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030. J Inflamm (Lond). 2016;13:20 pubmed publisher
Sharma P, Arias E, Cartee G. Protein Phosphatase 1-? Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle. Diabetes. 2016;65:2606-17 pubmed publisher
Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-Î²-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed publisher
Hadjiasgary A, Banafshe H, Ardjmand A. Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm. Iran J Basic Med Sci. 2015;18:130-7 pubmed
Oh W, Parajuli L, Zito K. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons. Cell Rep. 2015;10:162-9 pubmed publisher
Mirante O, Brandalise F, Bohacek J, Mansuy I. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Front Mol Neurosci. 2014;7:62 pubmed publisher
Sharanek A, Azzi P, Al Attrache H, Savary C, Humbert L, Rainteau D, et al. Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells. Toxicol Sci. 2014;141:244-53 pubmed publisher
Codeluppi S, Fernández Zafra T, Sandor K, Kjell J, Liu Q, Abrams M, et al. Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling. PLoS ONE. 2014;9:e92649 pubmed publisher
Chiodi V, Mallozzi C, Ferrante A, CHEN J, Lombroso P, Di Stasi A, et al. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology. 2014;39:569-78 pubmed publisher
van Vliet S, Vuist I, Lenos K, Tefsen B, Kalay H, Garcia Vallejo J, et al. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem. 2013;288:27519-32 pubmed publisher
Cai Y, Chen S, Pan H. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther. 2013;345:161-8 pubmed publisher
Marra V, Burden J, Thorpe J, Smith I, Smith S, Hausser M, et al. A preferentially segregated recycling vesicle pool of limited size supports neurotransmission in native central synapses. Neuron. 2012;76:579-89 pubmed publisher
Pont J, McArdle C, Lopez Bernal A. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol Endocrinol. 2012;26:1743-56 pubmed
Lin L, Sun W, Kung F, Dell Acqua M, Hoffman D. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking. J Neurosci. 2011;31:1323-32 pubmed publisher

product information

brand :

Tocris

master code :

3631

SKU :

3631/10

rank :

0.061

product name :

FK 506

description :

Potent calcineurin inhibitor; immunosuppressant

target :

Protein Ser/Thr Phosphatase Inhibitors

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FK 506 is a potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNF (IC50 = 10 nM), IFN and Myc from activated T cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo . Identified as targeting human host cell proteins that interact with SARS-CoV-2. . Analog also available.

extended description :

Potent calcineurin inhibitor; immunosuppressant

chemical name text :

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-e

formula :

C 44 H 69 NO 12

formula text :

C44H69NO12

cas num :

104987-11-3

USD :

191 USD

product details :

Potent calcineurin inhibitor; immunosuppressant

alt names :

Tacrolimus, Fujimycin

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage