NPS 2143 hydrochloride | Tocris Bioscience 3626 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NPS 2143 hydrochloride

catalog :

3626

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Zhang X, Jin T, Shi N, Yao L, Yang X, Han C, et al. Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine. Front Physiol. 2018;9:1922 pubmed publisher
Yamamura A, Ohara N, Tsukamoto K. Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension. PLoS ONE. 2015;10:e0138384 pubmed publisher
Yarova P, Stewart A, Sathish V, Britt R, Thompson M, P Lowe A, et al. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. 2015;7:284ra60 pubmed publisher
Kim J, Ho H, Kim N, Liu J, Tu C, Yenari M, et al. Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection. Ann Clin Transl Neurol. 2014;1:851-66 pubmed publisher
Dai W, Bai Y, Hebda L, Zhong X, Liu J, Kao J, et al. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ. 2014;21:568-81 pubmed publisher
Diakogiannaki E, Pais R, Tolhurst G, Parker H, Horscroft J, Rauscher B, et al. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia. 2013;56:2688-96 pubmed publisher
Jouret F, Wu J, Hull M, Rajendran V, Mayr B, Schofl C, et al. Activation of the Ca²+-sensing receptor induces deposition of tight junction components to the epithelial cell plasma membrane. J Cell Sci. 2013;126:5132-42 pubmed publisher
Yamamura A, Guo Q, Yamamura H, Zimnicka A, Pohl N, Smith K, et al. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012;111:469-81 pubmed publisher

product information

brand :

Tocris

master code :

3626

SKU :

3626/10

product name :

NPS 2143 hydrochloride

description :

Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent

target :

Calcium-Sensing Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

445.38

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective Ca2+-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells (IC50 = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50 = 41 nM). Orally active calcilytic compound.

catalog number base :

3626

product keywords :

calcium Ca2+ sensing receptors CaSR antagonists orally active calcilytics NPS2143 Calcium-Sensing Receptor 3626,

extended description :

Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent

chemical name text :

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrile hydrochloride

formula :

C 24 H 25 ClN 2 O 2 .HCl

formula text :

C24H25ClN2O2.HCl

cas num :

324523-20-8

2020 USD :

207

2021 USD :

216 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage