product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
IPA 3
catalog :
3622
quantity :
10 mg (also 50 mg)
price :
129 USD
more info or order :
citations: 21
Reference
Zhang C, Lee H, Shrivastava A, Wang R, McQuiston T, Challberg S, et al. Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling. Cell Rep. 2018;25:598-610.e5 pubmed publisher
Das A, Dines M, Alapin J, Lamprecht R. Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala. Sci Rep. 2017;7:13930 pubmed publisher
Durkin C, Leite F, Cordeiro J, Handa Y, Arakawa Y, Valderrama F, et al. RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6. Dev Cell. 2017;41:315-329.e7 pubmed publisher
Zeng N, Salker M, Zhang S, Singh Y, Shi B, Stournaras C, et al. 1α,25(OH)2D3 Induces Actin Depolymerization in Endometrial Carcinoma Cells by Targeting RAC1 and PAK1. Cell Physiol Biochem. 2016;40:1455-1464 pubmed publisher
Martin K, Pritchett J, Llewellyn J, Mullan A, Athwal V, Dobie R, et al. PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. Nat Commun. 2016;7:12502 pubmed publisher
Salker M, Schierbaum N, Alowayed N, Singh Y, Mack A, Stournaras C, et al. LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells. Sci Rep. 2016;6:29370 pubmed publisher
Wang Y, Gratzke C, Tamalunas A, Wiemer N, Ciotkowska A, Rutz B, et al. P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS ONE. 2016;11:e0153312 pubmed publisher
Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, et al. A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation. Int J Cancer Clin Res. 2015;2:1-6 pubmed
Wang W, Townes Anderson E. LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury. Invest Ophthalmol Vis Sci. 2015;56:7847-58 pubmed publisher
Sorce B, Escobedo C, Toyoda Y, Stewart M, Cattin C, Newton R, et al. Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement. Nat Commun. 2015;6:8872 pubmed publisher
Reinardy J, Corey D, Golzio C, Mueller S, Katsanis N, Kontos C. Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. PLoS ONE. 2015;10:e0139614 pubmed publisher
Imle A, Abraham L, Tsopoulidis N, Hoflack B, Saksela K, Fackler O. Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio. 2015;6:e01309-15 pubmed publisher
Pandolfi A, Stanley R, Yu Y, Bartholdy B, Pendurti G, Gritsman K, et al. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. Blood. 2015;126:1118-27 pubmed publisher
Mortazavi F, Lu J, Phan R, Lewis M, Trinidad K, Aljilani A, et al. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. BMC Cancer. 2015;15:381 pubmed publisher
Molosh A, Johnson P, Spence J, Arendt D, Federici L, Bernabe C, et al. Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. Nat Neurosci. 2014;17:1583-90 pubmed publisher
Al Ejeh F, Miranda M, Shi W, Simpson P, Song S, Vargas A, et al. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget. 2014;5:3145-58 pubmed
Huttunen M, Waris M, Kajander R, Hyypia T, Marjomaki V. Coxsackievirus A9 infects cells via nonacidic multivesicular bodies. J Virol. 2014;88:5138-51 pubmed publisher
Berger A, Hoelbl Kovacic A, Bourgeais J, Hoefling L, Warsch W, Grundschober E, et al. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia. 2014;28:629-41 pubmed publisher
Martin H, Mali R, Ma P, Chatterjee A, Ramdas B, Sims E, et al. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. J Clin Invest. 2013;123:4449-63 pubmed publisher
DiPaolo B, Davidovich N, Kazanietz M, Margulies S. Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2013;305:L141-53 pubmed publisher
Wu R, Abramson A, Symons M, Steinberg B. Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression. Int J Cancer. 2010;127:2230-7 pubmed publisher
product information
brand :
Tocris
master code :
3622
SKU :
3622/10
product name :
IPA 3
description :
Group I PAK inhibitor
target :
PAK Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
96%
observed molecular weight :
350.45
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Group I p21-activated kinase (PAK) inhibitor (IC50 = 2.5 M at PAK1). Targets the autoregulatory mechanism and promotes the inactive conformation of PAKs. Inhibits PAK1-mediated signaling in vivo ; potential anti-tumor agent. . Negative Control also available.
catalog number base :
3622
product keywords :
Group I p21-activated kinases PAK PAK1 inhibitors inhibits IPA3 P21-activated Kinases 3622, p21-Activated Kinases, p21-Activated Kinase, PAKs
extended description :
Group I PAK inhibitor
chemical name text :
1,1 -Dithiodi-2-naphthtol
formula :
C 20 H 14 O 2 S 2
formula text :
C20H14O2S2
cas num :
42521-82-4
2020 USD :
124
2021 USD :
129 USD
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK