3621/10 | Tocris Bioscience 3621/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

3621/10

catalog :

3621/10

quantity :

10 mg (also 50 mg)

price :

232 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Pampaloni N, Riva I, Carbone A, Plested A. Slow AMPA receptors in hippocampal principal cells. Cell Rep. 2021;36:109496 pubmed publisher
Pollok S, Reiner A. Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization. Proc Natl Acad Sci U S A. 2020;117:25851-25858 pubmed publisher
Midorikawa M, Sakaba T. Kinetics of Releasable Synaptic Vesicles and Their Plastic Changes at Hippocampal Mossy Fiber Synapses. Neuron. 2017;96:1033-1040.e3 pubmed publisher
Crook J, Packer O, Dacey D. A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina. Vis Neurosci. 2014;31:57-84 pubmed publisher
Buldyrev I, Puthussery T, Taylor W. Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell. J Neurophysiol. 2012;107:1795-807 pubmed publisher

product information

master code :

3621

SKU :

3621/10

product name :

UBP 310

unit size :

10 mg (also 50 mg)

description :

GluK1-selective kainate antagonist

target :

Kainate Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

353.35

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UBP 310 is a GluK1 (formerly GLUK5) kainate receptor antagonist (IC50 = 130 nM); also blocks recombinant homomeric GluK3 (forrmerly GLUK7) receptors. Displays 12,700-fold selectivity for GluK1 (formerly GLUK5) over GluK2 (formerly GLUK6). Exhibits no activity at mGlu group I or NMDA receptors at concentrations of up to 10 M. Apparent KD value is 18 4 nM for depression of kainate responses on the dorsal root. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

top caption :

GluK1-selective kainate antagonist

extended description :

GluK1-selective kainate antagonist

chemical name text :

(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione

formula :

C14H15N3O6S

formula text :

C14H15N3O6S

cas num :

902464-46-4

USD :

232 USD

product details :

GluK1-selective kainate antagonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage