3620/10 | Tocris Bioscience 3620/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

3620/10

catalog :

3620/10

quantity :

10 mg (also 50 mg)

price :

131 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

3620

SKU :

3620/10

product name :

Topiramate

unit size :

10 mg (also 50 mg)

description :

GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors

target :

Kainate Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

339.36

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Topiramate is an anticonvulsant. Antagonizes GluK1 (formerly GluR5) kainate receptors (IC50 = 0.46 M), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 M) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

top caption :

GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors

extended description :

GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors

chemical name text :

2,3:4,5-Bis-O-(1-methylethylidene)- -D-fructopyranose sulfamate

formula :

C12H21NO8S

formula text :

C12H21NO8S

cas num :

97240-79-4

USD :

131 USD

product details :

GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors

alt names :

Topamax

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage