Rotenone | Tocris Bioscience 3616 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Rotenone

catalog :

3616

quantity :

50 mg

price :

65 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Battefeld A, Popovic M, de Vries S, Kole M. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep. 2019;26:182-191.e5 pubmed publisher
Martin T, Cook D, Choi M, Li M, Haigis K, Elledge S. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep. 2017;20:427-438 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher
Moloney J, Stanicka J, Cotter T. Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia. Leuk Res. 2017;52:34-42 pubmed publisher
Banh R, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman A, et al. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol. 2016;18:803-813 pubmed publisher
Beyer A, Durand M, Hockenberry J, Gamblin T, Phillips S, Gutterman D. An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol. 2014;307:H1587-93 pubmed publisher
Juliana C, Fernandes Alnemri T, Kang S, Farias A, Qin F, Alnemri E. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem. 2012;287:36617-22 pubmed publisher

product information

brand :

Tocris

master code :

3616

SKU :

3616/50

product name :

Rotenone

description :

Inhibits complex I of the mitochondrial electron transport chain

target :

Oxidative Phosphorylation Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

95%

observed molecular weight :

394.42

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 M at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.

catalog number base :

3616

product keywords :

inhibitors inhibits complex I mitochondrial electron transport chain Oxidative phosphorylation parkinson s parkinsons parkinsonism complex I Oxidative Phosphorylation 3616,

extended description :

Inhibits complex I of the mitochondrial electron transport chain

chemical name text :

(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

formula :

C 23 H 22 O 6

formula text :

C23H22O6

cas num :

83-79-4

2020 USD :

2021 USD :

65 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage