3616/50 | Tocris Bioscience 3616/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

3616/50

catalog :

3616/50

quantity :

50 mg

price :

87 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Shaiken T, Grimm S, Siam M, Williams A, Rezaeian A, Kraushaar D, et al. Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix. iScience. 2023;26:105965 pubmed publisher
de Wet L, Williams A, Gillard M, Kregel S, Lamperis S, Gutgesell L, et al. SOX2 mediates metabolic reprogramming of prostate cancer cells. Oncogene. 2022;41:1190-1202 pubmed publisher
Kondo H, Ratcliffe C, Hooper S, Ellis J, Macrae J, Hennequart M, et al. Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms. Cell Rep. 2021;34:108750 pubmed publisher
Rees D, Roberts L, Carla Carisì M, Morgan A, Brown M, Davies J. Automated Quantification of Mitochondrial Fragmentation in an In Vitro Parkinson's Disease Model. Curr Protoc Neurosci. 2020;94:e105 pubmed publisher
Holmes T, Brown A, Suggitt M, Shaw L, Simpson L, Harrity J, et al. The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate. Sci Rep. 2020;10:9926 pubmed publisher
Battefeld A, Popovic M, de Vries S, Kole M. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep. 2019;26:182-191.e5 pubmed publisher
Zhi L, Qin Q, Muqeem T, Seifert E, Liu W, Zheng S, et al. Loss of PINK1 causes age-dependent decrease of dopamine release and mitochondrial dysfunction. Neurobiol Aging. 2019;75:1-10 pubmed publisher
Martin T, Cook D, Choi M, Li M, Haigis K, Elledge S. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep. 2017;20:427-438 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher
Moloney J, Stanicka J, Cotter T. Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia. Leuk Res. 2017;52:34-42 pubmed publisher
Banh R, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman A, et al. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol. 2016;18:803-813 pubmed publisher
Lin Y, Schulz A, Pellegrino M, Lu Y, Shaham S, Haynes C. Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Nature. 2016;533:416-9 pubmed publisher
Beyer A, Durand M, Hockenberry J, Gamblin T, Phillips S, Gutterman D. An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol. 2014;307:H1587-93 pubmed publisher
Juliana C, Fernandes Alnemri T, Kang S, Farias A, Qin F, Alnemri E. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem. 2012;287:36617-22 pubmed publisher

product information

master code :

3616

SKU :

3616/50

product name :

Rotenone

unit size :

50 mg

description :

Inhibits complex I of the mitochondrial electron transport chain

target :

Oxidative Phosphorylation Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

394.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Rotenone is a mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 M at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.

top caption :

Inhibits complex I of the mitochondrial electron transport chain

extended description :

Inhibits complex I of the mitochondrial electron transport chain

chemical name text :

(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

formula :

C23H22O6

formula text :

C23H22O6

cas num :

83-79-4

USD :

87 USD

product details :

Inhibits complex I of the mitochondrial electron transport chain

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage