Kaempferol | Tocris Bioscience 3603 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Kaempferol

catalog :

3603

quantity :

50 mg

price :

106 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Tran K, Li Y, Duan H, Arora D, Lim H, Wang W. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014;9:2796-806 pubmed publisher

product information

brand :

Tocris

master code :

3603

SKU :

3603/50

product name :

Kaempferol

description :

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

target :

Other Ion Pump/Transporter Activators

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

286.24

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Activates the mitochondrial Ca2+ uniporter (EC50 = 7 M). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro . Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine.

catalog number base :

3603

product keywords :

Mitochondrial Ca2+ uniporter MCU activators proapoptotic downregulates PLK1 expression Ion Pumps Transporters Apoptosis Inducer TAZ activators activates transcriptional coactivator with PDZ-binding motif osteogenesis MSC mesenchymal stem cells Kempferol Apoptosis Inducers IRE1 Mitochondrial Calcium Uniporter RSK Hippo/Yap signaling Stem Cell Signaling 3603,

extended description :

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

chemical name text :

3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

formula :

C 15 H 10 O 6

formula text :

C15H10O6

cas num :

520-18-3

2020 USD :

102

2021 USD :

106 USD

alt names :

Kempferol

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage