3603/50 | Tocris Bioscience 3603/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

3603/50

catalog :

3603/50

quantity :

50 mg

price :

135 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Li W, Chen J, Sun C, Sparks R, Pantano L, Rahman R, et al. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. elife. 2022;11: pubmed publisher
Hao Y, Kuang Z, Jing J, Miao J, Mei L, Lee R, et al. Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins. Infect Immun. 2014;82:5246-55 pubmed publisher
Tran K, Li Y, Duan H, Arora D, Lim H, Wang W. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014;9:2796-806 pubmed publisher

product information

master code :

3603

SKU :

3603/50

product name :

Kaempferol

unit size :

50 mg

description :

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

target :

Other Ion Pump/Transporter Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

286.24

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Activates the mitochondrial Ca2+ uniporter (EC50 = 7 M). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro . Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine. Kaempferol has antiviral activity against Japanese encephalitis virus (JEV) in infected BHK21 (EC50 = 21.5 M). Kaempferol directly inhibits viral replication and protein expression by binding JEV frameshift site RNA (fsRNA). Kaempferol influences frameshift efficiency in virus-infected cells through interfering with a downstream RNA pseudoknot structure. Kaempferol has also been reported to exhibit activity against herpes simplex virus, influenza viruses (H1N1 and H9N2) and hepatitis B virus under in vitro conditions.

top caption :

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

extended description :

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

chemical name text :

3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

formula :

C15H10O6

formula text :

C15H10O6

cas num :

520-18-3

USD :

135 USD

product details :

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

alt names :

Kempferol

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage