W146 | Tocris Bioscience 3602 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

W146

catalog :

3602

quantity :

1 mg

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Schuhmann M, Bittner S, Meuth S, Kleinschnitz C, Fluri F. Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. Int J Mol Sci. 2015;16:29454-66 pubmed publisher
Hoffmann F, Hofereiter J, RÃ¼bsamen H, Melms J, Schwarz S, Faber H, et al. Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation. 2015;12:184 pubmed publisher
Beckham T, Cheng J, Lu P, Marrison S, Norris J, Liu X. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS ONE. 2013;8:e76593 pubmed publisher
Beckham T, Cheng J, Lu P, Shao Y, Troyer D, Lance R, et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2013;2:e49 pubmed publisher

product information

brand :

Tocris

master code :

3602

SKU :

3602/1

product name :

W146

description :

Potent and selective S1P1 receptor antagonist

target :

Sphingosine-1-phosphate Receptor Antagonists

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

342.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo .

catalog number base :

3602

product keywords :

potent selective sphingosine-1-phosphate s1p1 antagonists sphingolipids ML056 ML 056 Sphingosine-1-phosphate Receptors 3602,

extended description :

Potent and selective S1P1 receptor antagonist

chemical name text :

[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

formula :

C 16 H 27 N 2 O 4 P

formula text :

C16H27N2O4P

cas num :

909725-61-7

2020 USD :

166

2021 USD :

173 USD

alt names :

ML 056

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage