3602/1 | Tocris Bioscience 3602/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

3602/1

catalog :

3602/1

quantity :

1 mg

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Wang Y, Wang C, He Q, Chen G, Yu J, Cang J, et al. Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux. Front Immunol. 2023;14:1090202 pubmed publisher
Cautivo K, Matatia P, Lizama C, Mroz N, Dahlgren M, Yu X, et al. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 2022;55:254-271.e7 pubmed publisher
Molinar Inglis O, Birch C, Nicholas D, Orduña Castillo L, Cisneros Aguirre M, Patwardhan A, et al. aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Velagapudi S, Rohrer L, Poti F, Feuerborn R, Perisa D, Wang D, et al. Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein. Arterioscler Thromb Vasc Biol. 2021;41:e468-e479 pubmed publisher
Schuhmann M, Bittner S, Meuth S, Kleinschnitz C, Fluri F. Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. Int J Mol Sci. 2015;16:29454-66 pubmed publisher
Hoffmann F, Hofereiter J, RÃ¼bsamen H, Melms J, Schwarz S, Faber H, et al. Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation. 2015;12:184 pubmed publisher
Beckham T, Cheng J, Lu P, Marrison S, Norris J, Liu X. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS ONE. 2013;8:e76593 pubmed publisher
Beckham T, Cheng J, Lu P, Shao Y, Troyer D, Lance R, et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2013;2:e49 pubmed publisher

product information

master code :

3602

SKU :

3602/1

product name :

W146

unit size :

1 mg

description :

Potent and selective S1P1 receptor antagonist

target :

Sphingosine-1-phosphate Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

342.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

W146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo .

top caption :

Potent and selective S1P1 receptor antagonist

extended description :

Potent and selective S1P1 receptor antagonist

chemical name text :

[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

formula :

C16H27N2O4P

formula text :

C16H27N2O4P

cas num :

909725-61-7

USD :

219 USD

product details :

Potent and selective S1P1 receptor antagonist

alt names :

ML 056

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage