CYM 5442 hydrochloride | Tocris Bioscience 3601 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CYM 5442 hydrochloride

catalog :

3601

quantity :

10 mg (also 50 mg)

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Hübner K, Cabochette P, Diéguez Hurtado R, Wiesner C, Wakayama Y, Grassme K, et al. Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun. 2018;9:4860 pubmed publisher
Chumanevich A, Wedman P, Oskeritzian C. Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. Mediators Inflamm. 2016;2016:1503206 pubmed publisher
Li C, Li J, Kays J, Guerrero M, Nicol G. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation. 2015;12:70 pubmed publisher
Janes K, Little J, Li C, Bryant L, Chen C, Chen Z, et al. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem. 2014;289:21082-97 pubmed

product information

brand :

Tocris

master code :

3601

SKU :

3601/10

product name :

CYM 5442 hydrochloride

description :

Selective S1P1 receptor agonist

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

445.94

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.

catalog number base :

3601

product keywords :

sphingosine-1-phosphate S1P1 receptors agonists CYM5442 hydrochloride Sphingosine-1-phosphate Receptors 3601,

extended description :

Selective S1P1 receptor agonist

chemical name text :

2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride

formula :

C 23 H 27 N 3 O 4 .HCl

formula text :

C23H27N3O4.HCl

cas num :

1783987-80-3

2020 USD :

228

2021 USD :

238 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage