product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
FIPI
catalog :
3600
quantity :
10 mg (also 50 mg)
price :
257 USD
more info or order :
citations: 5
Reference
Lin S, Liu Y. Mechanical Stretch Induces mTOR Recruitment and Activation at the Phosphatidic Acid-Enriched Macropinosome in Muscle Cell. Front Cell Dev Biol. 2019;7:78 pubmed publisher
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed publisher
Wang X, Shaw D, Hammond H, Sutterwala F, Rayamajhi M, Shirey K, et al. The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog. 2016;12:e1005803 pubmed publisher
Bonnefond M, Lambert B, Giffard F, Abeilard E, Brotin E, Louis M, et al. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Apoptosis. 2015;20:535-50 pubmed publisher
Pastor A, Farre M, Fito M, Fernandez Aranda F, de la Torre R. Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res. 2014;55:966-77 pubmed publisher
product information
brand :
Tocris
master code :
3600
SKU :
3600/10
product name :
FIPI
description :
Phospholipase D inhibitor
target :
Phospholipase Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
457.93
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.
catalog number base :
3600
product keywords :
potent phospholipases D PLD1 PLD2 inhibitors inhibits esterases Phospholipases 3600,
extended description :
Phospholipase D inhibitor
chemical name text :
N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
formula :
C 23 H 24 FN 5 O 2 .HCl
formula text :
C23H24FN5O2.HCl
cas num :
1781834-93-2
2020 USD :
247
2021 USD :
257 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK