3595/1 | Tocris Bioscience 3595/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

3595/1

catalog :

3595/1

quantity :

1 mg (also 10 mg)

price :

168 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Orth He E, Huang H, Rao S, Wang Q, Chen Q, O Mara C, et al. Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Cell Rep. 2023;42:111965 pubmed publisher
Kishton R, Patel S, Decker A, Vodnala S, Cam M, Yamamoto T, et al. Cancer genes disfavoring T cell immunity identified via integrated systems approach. Cell Rep. 2022;40:111153 pubmed publisher
Rao S, Chen Q, Wang Q, Orth He E, Saoi M, Griswold A, et al. M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome. Nat Chem Biol. 2022;18:565-574 pubmed publisher

product information

master code :

3595

SKU :

3595/1

product name :

CHR 2797

unit size :

1 mg (also 10 mg)

description :

Aminopeptidase inhibitor

target :

Aminopeptidase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

406.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CHR 2797 is an aminopeptidase inhibitor (IC50 values are 100, 150, 220, 1000, 5000, 10000 and 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo . Also inhibits neprilysin (IC50 = 900 nM). Exhibits antinociceptive activity and enhances the efficacy of Morphine (Cat. No. 5158) in the hot-plate and tail-flick assays, via an action on the peripheral nervous system.

top caption :

Aminopeptidase inhibitor

extended description :

Aminopeptidase inhibitor

chemical name text :

-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-benzeneacetic acid cyclopently ester

formula :

C21H30N2O6

formula text :

C21H30N2O6

cas num :

238750-77-1

USD :

168 USD

product details :

Aminopeptidase inhibitor

alt names :

Tosedostat

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage