VO-OHpic | Tocris Bioscience 3591 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VO-OHpic

catalog :

3591

quantity :

10 mg (also 50 mg)

price :

160 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

3591

SKU :

3591/10

product name :

VO-OHpic

description :

Potent PTEN inhibitor

target :

Protein Tyrosine Phosphatase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

361.16

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTP and SAC (IC50 values are 588 nM, 4.03, 57.5 and 10 M respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

catalog number base :

3591

product keywords :

476310-60-08 potent inhibitors inhibits PTEN phosphate tensin homolog deleted chromosome 10 Protein Tyrosine Phosphatases 3591,

extended description :

Potent PTEN inhibitor

chemical name text :

(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato- -N1, O2)[3-(hydroxy- O)-2-pyridinecarboxylato(2-)- O2]oxovanadate(1-),hydrogen

formula :

C 12 H 10 N 2 O 8 V

formula text :

C12H10N2O8V

cas num :

675848-25-6

2020 USD :

155

2021 USD :

160 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage