3591/10 | Tocris Bioscience 3591/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

3591/10

catalog :

3591/10

quantity :

10 mg (also 50 mg)

price :

202 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Hlushchuk I, Barut J, Airavaara M, Luk K, Domanskyi A, Chmielarz P. Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons. Biomolecules. 2022;12: pubmed publisher
Tellios N, Belrose J, Tokarewicz A, Hutnik C, Liu H, Leask A, et al. TGF-? induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma. Sci Rep. 2017;7:812 pubmed publisher

product information

master code :

3591

SKU :

3591/10

product name :

VO-OHpic

unit size :

10 mg (also 50 mg)

description :

Potent PTEN inhibitor

target :

Protein Tyrosine Phosphatase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

361.16

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTP and SAC (IC50 values are 588 nM, 4.03, 57.5 and 10 M respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

top caption :

Potent PTEN inhibitor

extended description :

Potent PTEN inhibitor

chemical name text :

(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato- -N1, O2)[3-(hydroxy- O)-2-pyridinecarboxylato(2-)- O2]oxovanadate(1-),hydrogen

formula :

C12H10N2O8V

formula text :

C12H10N2O8V

cas num :

675848-25-6

USD :

202 USD

product details :

Potent PTEN inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage