A 922500 | Tocris Bioscience 3587/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 922500

catalog :

3587/10

quantity :

10 mg

price :

382 USD

citations: 4

Reference
Scott C, Vossio S, Rougemont J, Gruenberg J. TFAP2 transcription factors are regulators of lipid droplet biogenesis. elife. 2018;7: pubmed publisher
Velliquette R, Grann K, Missler S, Patterson J, Hu C, Gellenbeck K, et al. Identification of a botanical inhibitor of intestinal diacylglyceride acyltransferase 1 activity via in vitro screening and a parallel, randomized, blinded, placebo-controlled clinical trial. Nutr Metab (Lond). 2015;12:27 pubmed publisher
Camus G, Herker E, Modi A, Haas J, Ramage H, Farese R, et al. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013;288:9915-23 pubmed publisher
Poliakov E, Gubin A, Stearn O, Li Y, Campos M, Gentleman S, et al. Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates. PLoS ONE. 2012;7:e49975 pubmed publisher

product information

brand :

Tocris

master code :

3587

SKU :

3587/10

product name :

A 922500

description :

Potent DGAT-1 inhibitor

target :

Diacylglycerol O-Acyltransferase (DGAT) Inhibitors

category :

Small Molecules

sizes available :

10 mg

purity :

98%

observed molecular weight :

428.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.

extended description :

Potent DGAT-1 inhibitor

chemical name text :

(1R,2R)-2-[[4 -[[Phenylamino)carbonyl]amino] [1,1 -biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid

formula :

C 26 H 24 N 2 O 4

formula text :

C26H24N2O4

cas num :

959122-11-3

USD :

363

USD 2023 :

382 USD

product details :

Potent DGAT-1 inhibitor

alt names :

DGAT-1 Inhibitor 4a

storage :

Store at +4°C